Multiple Endocrine Neoplasia Type 2b: A Rare Case Report

V Manmadha Rao; M V V Gandhi; B Vivekanand

V Manmadha Rao Associate Professor, Department of Surgery
M V V Gandhi Assistant Professor, Department of Medicine
B Vivekanand Assistant Professor, Department of Endocrinology

Keywords: Medullary carcinoma thyroid, Multiple endocrine neoplasia TYPE 2B, Pheochromocytoma

Abstract

Multiple endocrine neoplasia Type 2b is a rare syndrome caused by mutations in RET proto oncogene. It is a rare case, which
is found 1 in 30,000. We report a case of 23-year-old male patient with goiter, right lower chest pain, paroxysmal spells and
hypertension. On examination, mucosal neuromas and Grade 2 hard goiter were observed. Patient’s thyroid profi le was normal.
Fine-needle aspiration cytology thyroid showed medullary carcinoma of the thyroid. Calcitonin levels were found to be elevated.
Contrast enhanced computed tomography neck showed 28 mm × 20 mm heterogeneous mass in the right lobe of the thyroid.
Histopathology and immune histochemistry confi rmed the pheochromocytoma.

Author Biographies

V Manmadha Rao, Associate Professor, Department of Surgery

Rangaraya Medical College, Kakinada, Andhra Pradesh, India

M V V Gandhi, Assistant Professor, Department of Medicine

Guntur Medical College, Guntur, Andhra Pradesh, India

B Vivekanand, Assistant Professor, Department of Endocrinology

Andhra Medical College, Visakhapatnam, Andhra Pradesh, India

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