Evaluation of the Eff ectiveness of Oral Tablet Clonidine as a Premedicant Drug: A Prospective Study of 100 Cases
Introduction: Premedication is used to provide sedation and anxiolysis and to enhance the quality of induction; maintenance
and recovery from anesthesia. The ideal pre-medicant should be orally effective has sedative; analgesic, anti-anxiety, antisialagogue
and anti-emetic properties. And maintain cardiovascular stability and normal respirations.
Objectives: To evaluate the effectiveness of oral clonidine as a preanesthetic medicant and as a drug, to attenuate the
hemodynamic responses associated with laryngoscopy and endotracheal intubation.
Materials and Methods: Study was performed on 100 patients of the age group 18-65 years in whom 4 μg/kg body weight of oral
clonidine (max 0.2 mg) was administered 90 min prior to induction of anesthesia. Degree of sedation, anxiolysis, antisialagogue
effect and changes in heart rate, systolic blood pressure (BP), diastolic BP, mean arterial pressure and electrocardiogram
changes before and after premedication with oral clonidine was noted. Descriptive statistical analysis was done using statistical
software namely SPSS 15.0, Stata 8.0, MedCalc 9.0.1 and Systat 11.0 were used for the analysis of the data and Microsoft
word and Excel are used to generate graphs, and tables.
Results: Clonidine produced signifi cant sedation with a P <0.05, before premedication 61% of patients had anxiety score
of 1 and 27% had a Score of 2 and after premedication 77% had a Score of zero and 19% had Score 1, which is signifi cant
anxiolysis. The association that is observed between clonidine as anti-sialogogue is mildly signifi cant statistically. Premedication
with clonidine produced decrease in pulse rate, decrease in systolic, diastolic and mean arterial pressure was highly signifi cant
statistically P < 0.001. These values remained lower than the basal value after 1 min up to 5 min after intubation.
Conclusion: The premedication with oral clonidine produces signifi cant sedation, anxiolysis, mild anti-sialagogue effect and
hemodynamic stability during laryngoscopy and endotracheal intubation with no adverse effects. Thus, oral clonidine may be
used as an ideal pre-anesthetic medication.
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