Perspective Study of Elevated First Trimester C-reactive Protein as Predictor of Gestational Diabetes in South Karnataka Population: A Retrospective Study
Abstract
Background: The C-reactive protein (CRP) derived from the liver is sensitive and systemic biomarker of inflammation and has
been associated with increased risk of developing diabetes mellitus in pregnancy.
Materials and Methods: Ninety-two pregnant women having gestational diabetes of the first trimester and same number of
normal pregnant women of controlled group were studied. Blood sugar (fasting and postprandial) and CRP, body mass index
(BMI), age, and period of gestation/weeks of gestation were compared in both groups.
Results: The BMI of gestational diabetes group was 26.05 (SD ± 3.40) and 22.80 (SD ± 2.14), t-test was 7.75, and P-value
was highly significant. Laboratory findings, blood glucose (fasting and post-meal), and CRP (mg/l) were higher in gestation
diabetes and P-values were highly significant (P < 0.00). CRP values were more or less constant in blood glucose (fasting and
post-meal) hence P-value was insignificant (P > 0.98).
Conclusion: CRP values were higher in gestational diabetes due to inflammation and oxidative stress. These finding are
important for obstetrics and gynecologist to treat such patient efficiently to prevent morbidity and mortality of fetus and
mother too.
References
2. Wang X, Bao W. Inflammatory makers and risk of Type-2. Diabetes Care
2013;36:166-75.
3. Ye X, Zong G. Development of new risk score for incidence of Type-2
Diabetes using updated diagnostic criteria in middle aged and older
Chinese. PLoS One 2014;9:7042-58.
4. Ouchi N, Khira S, Funahashi T, Nakamura T, Nishida M, Kumada M.
Reciprocal association of C reactive protein with adiponectin in bloodAmerican Diabetes Association. Standards of medical care in diabetes.
Diabetes 2006;29:42-54.
6. Ergum-Langtire B, Maclaren NK. Aetiology Pathogenesis of Diabetes
Mellitus Children; 2020.
7. Simons KM, Michels AW. Type-II diabetes: A predictable disease world J.
Diabetes 2015;6:380-90.
8. Gosmanov AR, Kitabchi AE. Hyperglycaemic Crisis Diabetic Keto-
Acidosis; 2020.
9. Ardakani M, Rashid M. Gestational diabetes. Hamozogan Med Sci
2007;13:555-62.
10. Ben-Haroush A, Yogevy M. Epidemiology of gestational diabetes mellitus
and its association with Type-2 diabetes. Diabet Med 2003;21:103-13.
11. Buhary BM, Almohareb O. Glycemic control and pregnancy out comes
in patients with diabetes in pregnancy. Ind J Endocrinal Metab 2016;20:
481-90.
12. Catalano PM, Tyzbir ED. Longitudinal changes in insulin release and
insulin resistance in non-obese pregnant women. Am J Obslet Gynacol
1991;165:1667-72.
13. Verma S, Devaroy S. Is C-reactive protein innocent bystander or proatherogenic
culprit? C-reactive protein promotes athero-thrombosis.
Circulation 2006;113:2135-50.