Thyroid Profile of Patients with Non-alcoholic Fatty Liver Disease

Paul Samaresh; Bhaumik Pradip; Bhattacharya Swatilekha

Paul Samaresh Agartala Government Medical College, Agartala, Tripura, India
Bhaumik Pradip Agartala Government Medical College, Agartala, Tripura, India
Bhattacharya Swatilekha Agartala Government Medical College, Agartala, Tripura, India

Keywords: Hypothyroid, Non-alcoholic fatty liver disease, Subclinical hypothyroid, Transaminase

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with various metabolic abnormalities such as obesity, insulin resistance, and dyslipidemia. The prevalence of NAFLD is increasing gradually, which may progress to non-alcoholic steatohepatitis (NASH), cirrhosis of liver, and hepatocellular carcinoma. The important association of NAFLD and metabolic disease can lead to endocrinopathy, including thyroid diseases.
Methodology: Serologically diagnosed NAFLD patient was evaluated biochemically for liver function and thyroid function to evaluate any association between these two.
Results: The study shows female preponderance (63.3%) NAFLD. It was observed that 77.50% were having normal transaminase level and 22.50% had raised transaminase levels (NASH). Subclinical hypothyroidism was present among 18.30%, overt hypothyroidism was 7.50%, and hyperthyroidism was 0.80%. Among the individuals with normal transaminase level, 20.50% were hypothyroid (15.10% subclinical and 5.40% overt), and persons with raised transaminase levels (NASH), 44.44% were hypothyroid (29.63% subclinical and 14.81% overt).
Conclusion: This study shows that though there was a female preponderance of NAFLD, raised transaminase was more common among male and so is the hypothyroidism. This may form a matrix to the future study for cause and effect relationship of NAFLD and thyroid disease.

Author Biographies

Paul Samaresh, Agartala Government Medical College, Agartala, Tripura, India

Post Graduate Resident, Department of Medicine,

Bhaumik Pradip, Agartala Government Medical College, Agartala, Tripura, India

Associate Professor, Department of Medicine,

Bhattacharya Swatilekha, Agartala Government Medical College, Agartala, Tripura, India

Junior Research Fellowships, Medical Research Center,

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