Antenatal Ultrasonogram Detection of Fetal Urinary Tract Dilatation – Evaluation to form Guidelines for Postnatal Risk Stratification and Treatment Plan: A Single-center Study

  • T Prince Jeba Anand Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India
  • X Infant Puspha Venisha Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India
  • S Vijayaraj Institute of Child Health, Chennai, Tamil Nadu, India
Keywords: Fetal pyelectasis, Hydronephrosis, Pelviureteric junction obstruction, Urinary tract dilatation

Abstract

Introduction: The incidence of antenatally detected genitourinary abnormalities is on the rise. Although this has led to earlier interventions and better prognosis, there is a lack of standardization and uniformity in the diagnosis of urinary tract dilatation (UTD) which has resulted in more confusion than before regarding the management. Entities such as “prominent pelvis,” “pelviectasis,” and “hydronephrosis” have been used without any objective criteria which lead to unnecessary and extensive postnatal evaluation.
Aim: This study aims to study the imaging features of those infants with antenatally diagnosed fetal urinary tract dilation and to standardize the protocol for postnatal follow-up and management.
Materials and Methods: A prospective study of 72 mothers who were antenatally diagnosed with fetal UTD were enrolled for the study and postnatal follow-up done by imaging with ultrasound, voiding cystourethrogram, and intravenous urogram.
Results: Among the 72 enrolled cases of 24 were categorized under UTD A1, nine children were managed conservatively with regular follow-up. Those categorized under UTD P1, six cases had normal postnatal scans at the 1st week of life and at 1 month, of which three cases had transient hydronephrosis and two had partial pelviureteric junction obstruction (PUJO). Of 14 children with intermediate-risk dilation UTD P2, 11 children had complete PUJO, two had partial PUJO, and one had bilateral vesicoureteric reflux (VUR), of which patients with complete PUJO required pyeloplasty and the rest needed only observation. Among the 20 neonates with UTD P3 high-risk dilatation, 10 cases of posterior urethral valve, six cases of complete PUJO, one case of obstructive megaureter, one case of VUR, one case of bilateral ureterocele, and one case of non-neurogenic bladder, all of which required surgical intervention except in case of VUR.

Author Biographies

T Prince Jeba Anand, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

Assistant Professor, Department of Radiodiagnosis,

X Infant Puspha Venisha, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

Assistant Professor, Department of Radiodiagnosis, 

S Vijayaraj, Institute of Child Health, Chennai, Tamil Nadu, India

Assistant Professor, Department of Pediatric Surgery,

References

1. Thomas DF. Prenatal diagnosis: Does it alter outcome? Prenat Diagn
2001;21:1004-11.
2. Fägerquist M, Fägerquist U, Odén A, Blomberg SG. Fetal urine production
and accuracy when estimating fetal urinary bladder volume. Ultrasound
Obstet Gynecol 2001;17:132-9.
3. Rabinowitz R, Peters MT, Vyas S, Campbell S, Nicolaides KH. Measurement
of fetal urine production in normal pregnancy by real-time ultrasonography.
Am J Obstet Gynecol 1989;161:1264-6.
4. Babcook CJ, Silvera M, Drake C, Levine D. Effect of maternal hydration on
mild fetal pyelectasis. J Ultrasound Med 1998;17:539-44.
5. Robinson JN, Tice K, Kolm P, Abuhamad AZ. Effect of maternal hydration
on fetal renal pyelectasis. Obstet Gynecol 1998;92:137-41.
6. Petrikovsky BM, Cuomo MI, Schneider EP, Wyse LJ, Cohen HL, Lesser M,
et al. Isolated fetal hydronephrosis: Beware the effect of bladder filling.
Prenat Diagn 1995;15:827-9.
7. McHugo J, Whittle M. Enlarged fetal bladders: Aetiology, management and
outcome. Prenat Diagn 2001;21:958-63.
8. Bronshtein M, Kushnir O, Ben-Rafael Z, Shalev E, Nebel L, Mashiach S,
et al. Transvaginal sonographic measurement of fetal kidneys in the first
trimester of pregnancy. J Clin Ultrasound 1990;18:299-301.
9. Dudley JA, Haworth JM, McGraw ME, Frank JD, Tizard EJ. Clinical
relevance and implications of antenatal hydronephrosis. Arch Dis Child
Fetal Neonatal Ed 1997;76:F31-4.
10. Ouzounian JG, Castro MA, Fresquez M, al-Sulyman OM, Kovacs BW.
Prognostic significance of antenatally detected fetal pyelectasis. Ultrasound
Obstet Gynecol 1996;7:424-8.
11. Ismaili K, Avni FE, Hall M, Brussels Free University Perinatal Nephrology
(BFUPN) Study Group. Results of systematic voiding cystourethrography in
infants with antenatally diagnosed renal pelvis dilation. J Pediatr 2002;141:21‑4.
12. Jaswon MS, Dibble L, Puri S, Davis J, Young J, Dave R, et al. Prospective
study of outcome in antenatally diagnosed renal pelvis dilatation. Arch Dis
Child Fetal Neonatal Ed 1999;80:F135-8.
13. Blane CE, Barr M, DiPietro MA, Sedman AB, Bloom DA. Renal
obstructive dysplasia: Ultrasound diagnosis and therapeutic implications.
Pediatr Radiol 1991;21:274-7.
14. Owen RJ, Lamont AC, Brookes J. Early management and postnatal
investigation of prenatally diagnosed hydronephrosis. Clin Radiol
1996;51:173-6.
15. Najmaldin A, Burge DM, Atwell JD. Fetal vesicoureteric reflux. Br J Urol
1990;65:403-6.
16. Adra AM, Mejides AA, Dennaoui MS, Beydoun SN. Fetal pyelectasis: Is it
always “physiologic”? Am J Obstet Gynecol 1995;173:1263-6.
17. Graif M, Kessler A, Hart S, Daitzchman M, Mashiach S, Boichis H, et al.
Renal pyelectasis in pregnancy: Correlative evaluation of fetal and maternal
collecting systems. Am J Obstet Gynecol 1992;167:1304-6.
18. Benacerraf BR, Mandell J, Estroff JA, Harlow BL, Frigoletto FD Jr. Fetal
pyelectasis: A possible association with down syndrome. Obstet Gynecol
1990;76:58-60.
19. Coret A, Morag B, Katz M, Lotan D, Heyman Z, Hertz M. The impact
of fetal screening on indications for cystourethrography in infants. Pediatr
Radiol 1994;24:516-8.
20. Steele BT, Robitaille P, DeMaria J, Grignon A. Follow-up evaluation of
prenatally recognized vesicoureteric reflux. J Pediatr 1989;115:95-6.
Published
2021-09-08