Alteration in Serum Lipid Profile in Oral Squamous Cell Carcinoma

  • Sajan Vaish RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
  • Uma Gupta RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
  • Jawahar Singh Saini RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
  • Archnakumari Meena RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
  • Meenakshi Dahiya RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
  • Manju Bajiya RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India
Keywords: Control group, Histologically diagnosed case of oral cancer, Serum lipid profile

Abstract

Background: Alteration in the pattern of serum lipid profile has been associated with a variety of cancers and precancerous conditions. Low levels of serum lipid serve as a prognostic marker in the early detection of oral precancerous and cancerous conditions because lipid plays an important role in new membrane biogenesis and maintains cell integrity.
Aim: The aim of our study is to evaluate the alteration in serum lipid profile in oral squamous cell carcinoma (OSCC) and compared it with control group.
Materials and Methods: A total of 80 subjects were selected from the Department of Oral Pathology and Microbiology, RUHS College of Dental Sciences, Jaipur (GDC-Jaipur). Among 80 subjects, 40 individuals were diagnosed with squamous cell carcinoma and other 40 individuals were taken in healthy control group selected randomly from other departments. The total parameters assessed include total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), very LDLC, and triglycerides (TGLs). Statistical analysis was carried out by Chi-square and one-way ANOVA test to evaluate parameters.
Results: There was a significant decrease in TC, HDLC, and TGL in the oral cancer group as compared with the control group.
Conclusions: There was an inverse relationship between serum lipid profile and OSCC. The lower serum lipid status may be considered a useful prognostic biochemical indicator for initial changes occurring in the neoplastic proliferating cell.

Author Biographies

Sajan Vaish, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

BDS, MDS, Department of Oral Pathology and Microbiology, 

Uma Gupta, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

Senior Lecturer and Head, Department of Oral Pathology and Microbiology, 

Jawahar Singh Saini, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

BDS, MDS, Department of Oral Pathology and Microbiology, 

Archnakumari Meena, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

BDS, MDS, Department of Oral Pathology and Microbiology, 

Meenakshi Dahiya, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

BDS, MDS, Department of Oral Pathology and Microbiology, 

Manju Bajiya, RUHS College of Dental Sciences (a/k Government Dental College), RUHS University of Rajasthan, Jaipur, Rajasthan, India

BDS, MDS, Department of Oral Pathology and Microbiology, 

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Published
2021-09-08
Issue
Vol 7 No 7 (2019): (Volume 7, Issue 07) October 2019
Section
Original Articles