A Comparative Study between the Efficacy of Pre-incisional and Post-incisional Wound Infiltration of Bupivacaine for the Relief of Post-operative Pain

  • Shamala Dinkar Yashod Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India
  • Vaijayanti Nitin Gadre Grant Government Medical College, Mumbai, Maharashtra, India
Keywords: Bupivacaine, Post-incisional, Post-operative pain, Pre-incisional, Visual analog scale


Introduction: Pain, the “fifth vital sign” is an unpleasant sensation localized to a part of the body. Post-operative pain has been widely studied, as it causes adverse psychological and physiological effects. Many anesthetic agents and techniques have been developed to minimize the post-operative pain. This study compares the effectiveness of two such techniques: Pre-incisional and post-incisional infiltration using bupivacaine as the anesthetic agent.
Materials and Methods: This prospective, randomized, non-crossover type, double-blind interventional study was conducted on 60 patients of either gender, aged 15–50 years, belonging to the American Society of Anesthesiologists Grades I and II undergoing lower abdominal surgeries. They were randomly divided into two groups: Pre-incisional and post-incisional infiltration groups and were monitored for up to 24 h postoperatively for the duration of analgesia and intensity of pain.
Results: The duration of post-operative analgesia was better in the pre-incisional infiltration group (540 min) compared to the post-incisional infiltration group (360 min). Similarly, the overall mean pulse rate, mean systolic blood pressure (SBP), and mean respiratory rate were lower in the pre-incisional infiltration group, indicating better post-operative pain relief.
Conclusion: Although both pre-incisional and post-incisional infiltration of bupivacaine are safe, pre-incisional infiltration provides better relief of post-operative pain.

Author Biographies

Shamala Dinkar Yashod, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India

Assistant Professor, Department of Anesthesia, 

Vaijayanti Nitin Gadre, Grant Government Medical College, Mumbai, Maharashtra, India

Professor, Department of Anesthesia, 


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